In-Silico Prediction of Phytoconstituents from Manilkara Hexandra for Antidiabetic Activity Targeting GKRP (Glucokinase Regulatory Protein)

Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequate or dysfunctional insulin. Once more, medicinal plants are being researched for the treatment of diabetes. Prototypical compounds found in have been source many conventional medications. The part our investigation was to test phytoconstituents Manilkara hexandra antidiabetic efficacy, in-silico. Methods: pattern interaction between from (Roxb.) Dubard, plant and crystal structure proteins evaluated using molecular docking Discovery Studio (PDB ID: 4LY9). Later, SwissADME pkCSM were used screen toxicity well pharmacokinetic profile. Results: docked results suggest that quercetin (-9.3 kcal/mol), kaempferol (-9.1 p-coumaric acid (-6.4 kcal/mol) cinnamic (-6.3 4LY9 macromolecule has best binding towards activity compared standard drug metformin (-5.0 kcal/mol). According ADMET tests, pharmacokinetics characteristics also within acceptable bounds. Conclusion: Results potential aimed at encouraging. It promotes usage offers crucial details on pharmaceutical research clinical care.